Web Analytics


Warden Lab





Seo C*, Guru A*, Jin M, Ito B, Sleezer BJ, Ho YY, Wang E, Boada C, Krupa NA, Kullakanda DS, Shen CX, Warden MR. Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode. Science. 2019 Feb 1;363(6426):aau8722. [ PDF | Supplementary Materials ]

* equal contribution




Post RJ, Warden MR. Melancholy, anhedonia, apathy: the search for separable behaviors and neural circuits in depression. Curr. Opin. Neurobiol. 2018 Apr;49:192-200. [ PDF ]


Lundqvist M, Herman P, Warden MR, Brincat SL, Miller EK. Gamma and beta bursts during working memory readout suggest roles in its volitional control. Nat. Commun. 2018 Jan 26;9(1):394. [ PDF ] [ bioRxiv PDF ]




Lindsay, GW, Rigotti M, Warden MR, Miller EK, Fusi S. Hebbian Learning in a Random Network Captures Selectivity Properties of Prefrontal Cortex. J Neurosci, 2017 Nov 8;37(45):11021-11036. [ PDF ]




Ferenczi EA, Zalocusky KA, Liston C, Grosenick L, Warden MR, Amatya D, Katovich K, Mehta H, Patenaude

B, Ramakrishnan C, Kalanithi P, Etkin A, Knutson B, Glover GH, Deisseroth K. Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior. Science. 2016 Jan 1;351(6268):aac9698. [ PDF ]




Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, Arey RN, Enwright JF 3rd, Jacobsen JP, Kumar S, Remillard EM, Caron MG, Deisseroth K, McClung, CA. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Mol Psychiatry. 2015 Nov;20(11):1406-19. [ PDF ]


Guru A, Post RJ, Ho YY, Warden MR. Making sense of optogenetics. Int J Neuropsychoph. 2015 Jul 25:1-8 [ PDF ]


Sidor MM, Warden MR. Optogenetics. In: Price, L.H., Stolerman I. (ed) Encyclopedia of Psychopharmacology 2015. Berlin: Springer-Verlag. [ PDF ]


Sidor MM, Davidson TJ, Tye KM, Warden MR, Deisseroth K, McClung CA. In vivo optogenetic stimulation of the rodent central nervous system. J Vis Exp. 2015 Jan 15;95:e51483.




Warden MR, Cardin JA, Deisseroth K. Optical Neural Interfaces. Annu Rev Biomed Eng. 2014 Jul 11;16:103-129. [ PDF ]


Lammel S, Tye KM, Warden MR. Progress in understanding mood disorders: optogenetic dissection of neural circuits. Genes Brain Behav. 2014 Jan;13(1):38-51. [ PDF ]




Rigotti M, Barak O, Warden MR, Wang XJ, Daw N, Miller EK, Fusi S. The importance of mixed selectivity in complex cognitive tasks. Nature. 2013 May 30;497(7451):585-590. [ PDF | Supplementary Information ]


Kim SY*, Adhikari A*, Lee SY, Marshel JH, Kim CK, Mallory CS, Lo M, Pak S, Mattis J, Lim BK, Malenka RC, Warden MR, Neve R, Tye KM, Deisseroth K. Diverging neural pathways assemble a behavioral state from separable features in anxiety. Nature. 2013 Apr 11;496(7444):219-223. [ PDF | Supplementary Information ]


Tye KM*, Mirzabekov JJ*, Warden MR*, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature. 2013 Jan 24;493(7433):537-541. [ PDF | Supplementary Information ]

* equal contribution




Warden MR, Selimbeyoglu A, Mirzabekov JJ, Lo M, Thompson KR, Kim SY, Adhikari A, Tye KM, Frank LM, Deisseroth K. A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature. 2012 Dec 20/27;492(7429):428-432. [ PDF | Supplementary Information ]

          Current Biology commentary

          Nature Reviews Neuroscience commentary


Anikeeva P, Andalman AS, Witten I, Warden M, Goshen I, Grosenick L, Gunaydin LA, Frank LM, Deisseroth K. Optetrode: a multichannel readout for optogenetic control in freely moving mice. Nat Neurosci. 2011 Dec 4;15(1):163-70. [ PDF | Supplementary Information ]




Warden MR, Miller EK. Task-dependent changes in short-term memory in the prefrontal cortex. J Neurosci. 2010 Nov 24;30(47):15801-10. [ PDF ]




Siegel M, Warden MR, Miller EK. Phase-dependent neuronal coding of objects in short-term memory. Proc Natl Acad Sci U S A. 2009 Dec 5;106(50):21341-6. [ PDF | Supplementary Information ]




Warden MR, Miller EK. The representation of multiple objects in prefrontal neuronal delay activity. Cereb Cortex. 2007 Sep;17 Suppl 1:i41-50. [ PDF ]